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South American Indians have used cocaine as it occurs in the leaves of coca for at least 5000 years. In its native habitat, the coca plant is resistant to drought and disease. It needs no irrigation. Coca can be harvested several times a year. The active ingredient from the coca plant was first isolated by a chemist named Albert Niemann. In 1860 he gave the compound the name cocaine. The drug induces a sense of exhilaration in the user primarily by blocking the reuptake of the neurotransmitter dopamine in the midbrain. Soon after it was isolated, cocaine was used to try to cure almost all the illnesses and maladies that were known to man.

In the USA, cocaine was sold over-the-counter until 1914. It was widely used in tonics, toothache cures, patent medicines, and chocolate cocaine tablets. Prospective buyers were advised that cocaine "could make the coward brave, the silent eloquent, and render the sufferer insensitive to pain". When combined with alcohol, it yielded a further potently reinforcing compound, now known to be cocaethylene. Thus cocaine was a popular ingredient in wines, notably Vin Mariani. Coca wine received endorsement from prime-ministers, royalty and even the Pope.

Coca-Cola was invented in 1885 and first sold to consumers in 1886. At that time, it was sold as a patent medicine. It was promoted as a temperance drink offering the virtues of coca without the vices of alcohol. The new beverage was invigorating and popular. Until the early 1900's, one of the ingredients was cocaine.

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