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All are made in the liver except for Factor VIII (made by the vascular endothelium) and vonWillebrand's factor which is made in the endothelium (in the Weibel-Palade bodies), megakaryocytes (α-granules of platelets), and subendothelial connective tissue.

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15y ago
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1d ago

Clotting factors are primarily made in the liver. These proteins are essential for the blood clotting process to prevent excessive bleeding.

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Wiki User

13y ago

Liver

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Q: Where are clotting factors made in the body?
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