This is a slightly controversial subject in southern England! The Mayflower departed from Southampton but then returned to Plymouth while a sister ship was repaired. The Mayflower then departed from Plymouth around a month later. So you can argue for either Southampton or Plymouth.
To add to the confusion, the Mayflower then stopped off at Newlyn in Cornwall for water.
The Mayflower
the mayflower set sail September 6, 1620
the mayflower
no
It took 2 months for the mayflower to sail to America. See related link.
The Mayflower
1620
1620.
it sailed to Plymouth mass.
The mayflower
the famous mayflower
Southampton.