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The Natchez Trace starts in Natchez, Mississippi, and goes to Nashville, Tennessee. In the early years of the United States, Natchez, Mississippi, was as far upstream as ocean vessels could go. Farmers would take their crops there to sell. Ocean vessels would take them to the East Coast of the United States and even all over the world. They would return from there overland to Nashville, Tennessee, on the Natchez, Trace.
East of Muscle Shoals, Alabama, the Tennessee River was navigable to Western Virginia. The Cumberland fed into the Ohio. So from Muscle Shoals or Nashville, people would use river transportation to return home.
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