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The answer to this question depends on what time period you are speaking of. During the life of Jesus, the answer would have to be Jerusalem.

During the ministry of Paul the Apostle, Anioch, because Paul's missionary journeys to the gentiles began in this city. Also important is Jerusalem because of the Jerusalem Council. Here, Paul succeeded in persuading other Apostles to carry the Gospel to gentiles without any requirements of Hebrew law.

Second century Christianity was decentralized with key cities being Antioch, Jerusalem and Rome.

By the third and fourth centuries, the Church of Rome progressively became the center of the Christian religion.

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