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Amphetamine was first synthesised from ephedrine in 1887 by German chemist L. Edeleano. In 1919, amphetamine was chemically altered and developed into methamphetamine in Japan by Akira Ogata (1887-1978), where it was distributed for mass consumption as a central nervous system stimulant.

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Crystal methamphetamine was first synthesized in 1919 by Akira Ogata.


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