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There are at least three characters based on real life people:

Nicolas Flamel is based on real-life French alchemist of the 14th century Nicolas Flamel.

Perenelle Flamel is based on real-life French alchemist Nicolas Flamel's wife, Perenelle. Perenelle Flamel was also believed to be a powerful sorceress

Gilderoy Lockhart is based on someone J.K. Rowling knows in real life, and she says that the person she has based Lockhart on is so proud of himself that she has barely exaggerated in Lockhart's personality. Rowling, however, hasn't told anybody as of date of this edit who she has based on. There had been rumors that Lockhart is based on her ex-husband Jorge Arantes, though Rowling confirmed this to be wrong on her official website.

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