Scott Bakula, Jeri Ryan, Marina Sirtis.
Jonathan Frakes directed an episode of NCIS.
The cast of Star Trek Evolutions - 2009 includes: Leonard Nimoy as Narrator
The cast of Star Trek... ou presque - 2006 includes: Olivier Baroux Kad Merad
"Star Trek Generations" in 1994 .
After the Star Trek film franchise was rebooted in 2009, in the 2016 Star Trek Beyond is was revealed Lt. Hikaru Sulu was gay with a very brief look at his husband & daughter.Lt. Hawk whose character appeared in Star Trek First Contact, was revealed to be gay in the books but not in the movie.There were no gay characters in a Star Trek series until the debut of Star Trek Discovery when Lt. Paul Stamets & Dr. Hugh Culber were introduced.
The cast of Star Trek for a Cause - 2009 includes: John Frizell as Himself - Greenpeace Karen Sack as Herself - Greenpeace
The cast of Star Trek World Tour - 1998 includes: John de Lancie as Q Armin Scheuten as Star Fleet officer
Whoopi Goldberg first appeared in Star Trek with the 1988 Star Trek: The Next Generation episode "The Child".
The cast of All-Star American Destiny Trek - 2006 includes: Will Arnett as TJ Cooter Jill Talley as Victoria
The cast of The Star Trek Encyclopedia - 1999 includes: Majel Barrett as Memory Alpha Computer Marj Dusay as Kara Mark Lenard as Narrator
No. David Letterman never appeared on any Star Trek series or movies
Sharon Tate never appeared on Star Trek.
Chad Lowe never appeared on Star Trek Enterprise.