Osteoclasts
Osteoclast
Bone resorption is accomplished by specialized cells called osteoclasts. These cells are responsible for breaking down and removing old or damaged bone tissue, allowing for new bone formation and remodeling. The process of bone resorption helps regulate calcium levels in the body and is essential for maintaining bone health.
Bone cells that liquefy the bone matrix and release calcium into the blood are called Osteoclasts. Immature or matrix depositing bone cells are called osteoblasts.
The cells involved in bone breakdown and resorption are primarily osteoclasts. These multinucleated cells originate from monocyte/macrophage lineage and are responsible for the degradation of bone tissue by secreting acids and enzymes that dissolve mineralized bone matrix. This process is crucial for bone remodeling and maintaining calcium homeostasis in the body. Osteoclast activity is balanced by osteoblasts, which are responsible for bone formation.
Osteoclasts are the cells responsible for eroding bone minerals through a process called bone resorption. These specialized cells break down the bone matrix, releasing minerals like calcium back into the bloodstream.
Bone resorption is promoted by the parathyroid hormone, also called PTH. Bone resorption is the process by which osteoclasts break down bone and release the minerals, resulting in a transfer of calcium from bone fluid to the blood.
Bone cells called osteoclasts secrete acids and enzymes to break down bone tissue, releasing minerals such as calcium and phosphorus into the bloodstream. This process, known as bone resorption, helps regulate mineral levels in the body and allows for remodeling and repair of bone tissue.
Parathyroid hormone (PTH) stimulates bone remodeling by promoting the activity of osteoclasts, the cells responsible for bone resorption. When PTH levels rise, it increases calcium release from bones into the bloodstream, helping to maintain calcium homeostasis. Additionally, PTH influences osteoblast activity, leading to new bone formation in response to the resorption process. This dynamic balance between resorption and formation is crucial for bone health and strength.
Bone resorbing cells are known as osteoclasts. Immature bone cells are referred to as osteoblasts. Mature bone cells are called osteocytes.
Ostioclasts are the cells that lay down the calcium salts that are the bony part of bone. Ostioblasts are the cells that dissolve the bony salts. Note : condroclasts and chondroblasts do the same thing for the collagen matrix of bone. They all work together to form and modify bone.
In general, it increases calcium in the blood by increasing bone resorption. The exception is when pth is given in spiked pulses, which is the case in some medications (forteo, a pth analogue) which can paradoxically decrease bone resorption.
The bone cells capable of breaking down bonds are called osteoclasts. These specialized cells are responsible for bone resorption, which is the process of breaking down bone tissue to release minerals like calcium into the bloodstream. Osteoclasts play a critical role in bone remodeling and maintenance of bone health.