There aren't many but a quick look at the list of animated programs on Wikipedia finds ... Dot, Boj, Zou, Mad & Boo. I only went back 20 years.
Ben 10 technically only has three letters in its name along with two numbers.
There's G2G but that's of course two letters and a number. There's also BB3B which is technically three letters & one number.
That's hard.
cartoon
Transformers and Trollkins .
Cartoon Doll Emporium
Snoopy
Odie from Garfield
AquamanNed Flanders
Morocco Mole
Cartoon Cartoon Fridays - 2000 3-18 was released on: USA: 5 May 2006
Cartoon Cartoon Fridays - 2000 3-19 was released on: USA: 12 May 2006
Cartoon Cartoon Fridays - 2000 3-21 was released on: USA: 26 May 2006
Cartoon Cartoon Fridays - 2000 3-30 was released on: USA: 28 July 2006