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Bubonic Plague
The most popular theory is that the mongols contracted the disease from fleas which then went on rats and traveled the trade routes through all of Europe.
The Himalayas and the Gobi Desert
Trade Netwok.
Sea routes to the Far East from Europe (through the Suez Canal and Malacca Straits) are the busiest.
The Nile, the Colorado River and the Rio Grande all flow through deserts along much of their routes.
trade route
Silk Road: Connected Eurasia from China to the Mediterranean Sea. Trans-Saharan Trade Route: Connected North Africa with West Africa across the Sahara Desert. Maritime Silk Road: Connected East Asia with the Middle East, Africa, and Europe via sea routes. Amber Road: Connected the Baltic Sea with the Mediterranean region through Central Europe.
You can find information regarding European trains on Rail Europe's website as well as Eurail's website. You could also speak with a travel agent to help you find and or plan specific routes through Europe.
There was a route during the Middle Ages called the Silk Road, which went from China, across Central Asia to Eastern Europe. There was transportation through the area before the Silk Road opened, also, but it was less important. Some ancient transportation went through Persia, but it did not distribute much between China and Europe, tending more to distribute between Persia and both destinations. This meant that the Chinese goods and European goods stopped in Persia and did not go farther. Trade routes connected China with India by land and sea. From India, there were sea routes to the Middle East.
Europe lost access to overland trade routes to Asia.
assuming you mean places it started in Italy and moved along the trade routes through southern Europe (France, Spain) only hitting Northern Europe (Germany) decades later and with a much more religious tone