Which is a syndrome with polydactyly coarse facies hirschsprung's disease?
Clinical doesn't fit Hirschsrung's disease. Smith-Lemli Opitiz syndrome presents from birth with coarse facies and polydactyly.
Facies are your facial expressions (http://en.wikipedia.org/wiki/Facies), which can indicate conditions such as Williams syndrome (http://en.wikipedia.org/wiki/Williams_syndrome) and other forms of mental retardation. Coarse facies, in particular, are often associated with mental retardation. Coarse facies simply means that the facial expressions are coarse, which could represent congenital hypothyroidism (http://bdoza.blogspot.com/2008/12/casecongenital-hypothyroidism.html) or spondyloepimetaphyseal dysplasia (http://www.nature.com/ejhg/journal/v13/n5/fig_tab/5201339f1.html). Coarse facies, while often associated with mental retardation, is not the sole indicator, however, and other tests should be run as well.
I want to take a course on how to make a bulletin board of cork and coarse fabric. He is so coarse he should take a course in etiquette. The sand trap on the golf course is filled with coarse sand. I will course my coarse coated Airedales at the field trials. [Course is usually used as a noun but can also be used as a verb. Coarse is used as an adjective.]