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Fentanyl patches are better for pain (chronic pain) due to the idea that the patch releases a steady stream of medicine over time whereas taking a methadone tablet what happens is that you get the first pass effect, meaning that your liver begins to detoxify the methadone right from the beginning. Also, if you forget to take the tablet exactly on schedule then you could end up chasing the pain, ie. it is much easier and takes much less drug to maintain your analgesia rather than trying to catch up after forgetting to take your tablets, even for just an hour or so.

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Q: Which is better for controlled pain Fentanyl Patch or Methadone?
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