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The most common cause of clubbing is lung cancer. It is also commonly caused by other lung/Heart diseases like interstitial lung disease or really any disease that causes chronic hypoxia.

Hypoxia is a word used to describe the lack of sufficient oxygen supply in the body. Clubbing is caused by lack of oxygen in the blood, so on a basic note, any disease that causes the blood to be depraved of enough oxygen can cause hypoxia.

The people most likely to exhibit clubbing are people with lung cancer, as lung cancer is responsible for over 50% of the cases.

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