Which subway do you take from 21st Street-Queensbridge to 225 Cadman Plaza?

Answer 1

Take the Manhattan-bound F (of the B-D-F-M, the orange line) from 21st Street-Queensbridge to York Street in Brooklyn.

You will get off the train on Jay Street, near the corner of Jay and Sands Streets, on the west side of the Manhattan Bridge.

Walk north on Jay Street to Prospect Street, turn left, and walk west on Prospect Street to Cadman Plaza East or Cadman Plaza West (I don't know which one you're going to), then turn left and walk south on Cadman Plaza East or West to 225. The address 225 Cadman Plaza West is a lot further north than 225 Cadman Plaza East.