The Olmecs preceded the Toltecs who preceded the Aztecs.
I would nominate the Mayan civilization which was far more widespread and lasted much longer. Even after they went into decline, their influence continued to be felt for hundreds of years afterward.
Perhaps the Inca were "first".
Mayas
The first people to inhabit the Western Hemisphere was the Spanish.
Men arrived in the Western Hemisphere by walking and they got the in 1250 ad
in Mexico
The first major city in the western hemisphere is believed to be Teotihuacan in present-day Mexico. Built around 100 BCE, Teotihuacan was one of the largest cities of its time and was an important cultural and religious center in Mesoamerica.
in Mexico
Christopher Columbus
The first book printed in the Western hemisphere was the Bay Psalm Book, which was printed in Cambridge, Massachusetts, in 1640.
Christopher Columbus first reached the shores of the western hemisphere in October of 1492. He landed on the island that eventually became Hispaniola.
The first inhabitants of the Western Hemisphere came from Asia. At a time when the Bering Strait was frozen, they were able to walk from Siberia to Alaska.
Christopher Columbus first reached the shores of the western hemisphere in October of 1492. He landed on the island that eventually became Hispaniola.
Cuba is the first.