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You don't say where and when. If it's about the discovery of the East in the 15th and early 16th century, the answer is: the Portuguese.
The East African slave trade in the 1600 operated within Africa, Europe, and Asia, while the Atlantic slave trade in the 1700s also included in the Americans.
Spices
the muslim
Europeans first embark on exploration to the East as they looked for trade routes
The Ottomans grew wealthy by taxing trade between Europe and East Asia.
The late 16th and early 17th centuries saw competition between European countries for trade with the Indian subcontinent and the far east. England had India pretty well under their control by the end of the 17th century.
Kilwa seized the port of Sofala in the early 16th century to control the lucrative gold trade in the region and to expand its influence along the East African coast. By controlling Sofala, Kilwa gained access to the gold mines of the interior and could monopolize the trade of this precious commodity with foreign merchants.
William Barents
Francis Xavier was a 16th century Jesuit missionary who served in the far east.
The first European nation to attempt to break the Italian monopoly on trade with the far east in the 15th century was?
Germany
The tulip is of the genus Tulipa. They originated in the Middle East and were brought to Europe in the 16th century.
trade
100 years
From 16th century East Anglian dialect of English, for a clump of grass. The laster meaning of a "small blob" came into use in the 19th century.
The Portuguese conquest of Sofala, Kilwa, and Mombasa in the 16th century was significant because it solidified Portuguese control over the Indian Ocean trade routes. It allowed Portugal to establish a lucrative trade network and exert dominance in the region. Additionally, these conquests helped Portugal gain access to valuable resources and establish strategic bases along the East African coast.