Watson and Crick came up with the base-pairing rule for nucleic acids using Chargaff's rule that in DNA the percentages of adenine and thymine are equal, and the percentages of guanine and cytosine are equal.
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Erwin Chargaff discovered the basis for the base-pairing rule. This rule states that in DNA, Adenine always pairs with Thymine and Cytosine always pairs with Guanine. This rule was originally called Chargaff's rules, named so after the person who discovered them.
Chargaff made the discovery that the percentage of Adenine and Thymine in DNA was almost always the same, and that Cytosine and Guanine also were the same. While he didn't understand why at the time of his experiments, he provided a key piece of the puzzle into figuring out the structure of DNA.
Erwin Chargaff showed that the number of guanine units was equal to the number of cytosine units, and that the number of adenine was equal to the number of thymine. This hinted at a base pairing rule - but Chargaff did not explicitly state a rule.
Watson and Crick later proposed the base pairing rule.
Erwin Chargaff developed the rule that guanine and cytosine always occur in equal percentages, and adenine and thymine always occur in equal percentages, but James Watson and Francis Crick developed the base-pairing rule when they determined the structure of DNA.
Erwin Chargaff, who created "Chargaff's Ratios" to show that A=T and C=G.
Erwin Chargaff
Erwin Chargaff
Chargaff
Base Pairing Rules
Erwin Chargaff
Adenine pairs with thymine Guanine pairs with cytosine.
The base pairing rule is known as complementary base pairing. In DNA, the following base pairing rules apply: Adenine (A) pairs with Thymine (T) Cytosine (C) pairs with Guanine (G) In RNA, Uracil replaced Thymine so the base pairing rules here become Uracal (U) to Adenine (A).
The rule A-T; C-G is a complementary base pair, and is semi-conservative replication. The Hydrogen bonds will always pair in these exact pairs.
Base Pairing Rules
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Erwin Chargaff
in the 1950's
Adenine pairs with thymine Guanine pairs with cytosine.
Yes.;) Possibly.
watson-base pairing
yes
The base pairing rule is known as complementary base pairing. In DNA, the following base pairing rules apply: Adenine (A) pairs with Thymine (T) Cytosine (C) pairs with Guanine (G) In RNA, Uracil replaced Thymine so the base pairing rules here become Uracal (U) to Adenine (A).
A goes to U and G goes to C. DNA its A=T G=C.
mRNA makes a complimentary copy of the DNA molecule according to the base-pairing rule.
Why is complementary base pairing crucial for life?