Lady Macbeth
Lady Macbeth drugs the guards stationed outside King Duncan's chamber to ensure they are unconscious and unable to interfere with her plan to frame them for Duncan's murder. This allows Macbeth to easily access Duncan's chamber and carry out the assassination.
Lady Macbeth takes the bloody dagger back to Duncan's room in order to frame the King's guards for his murder.
Lady Macbeth planned to blame the murder on the grooms of Duncan's chamber. This frame-up was successful, at least at first.
Lady Macbeth enters the King's room to plant the daggers on the guards after she has drugged them. This is part of the plan she and Macbeth devised to frame the guards for the murder of King Duncan.
The reaction between Lady Macbeth and Macbeth is initially very different after they kill Duncan. Lady Macbeth is enthusiastic but Macbeth regrets his actions.
In Act 2 of Macbeth, King Duncan is murdered by Macbeth in his sleep. Lady Macbeth also kills the two sleeping guards to frame them for the murder.
The night of Duncan's murder he is spending the night at MacBeth and Lady MacBeth's castle.
"I" said Macbeth, "with the servants' daggers. I killed Macbeth."
Lady Macbeth
Macbeth and Lady Macbeth plan to murder King Duncan by inviting him to their castle as guests, then waiting until he is asleep to kill him. They plan to frame the chamberlains for the murder by planting the murder weapons on them.
father