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Dr. William Murrell was first credited for experimenting with and later utilizing nitroglycerin as a treatment for angina. His results were published in The Lancet and, subsequently, the treatment became popular due to its efficacy. The nitroglycerin was marketed as Trinitrin to allay the potential fears of patients and it is effective at generating nitric oxide, a powerful vasodilatory agent for lowering blood pressure and increasing blood flow around blocked arteries that usually cause angina.

It does also give you a wicked headache.

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