Murphy
nolan Ryan
The most strikeouts in baseball history in one inning is four. This has happened just 72 times in baseball history.
For the stat "Strikeouts per 9 Innings" for pitchers that have pitched at least 1000 innings the all time leader, through games played on September 22, 2009 is Randy Johnson with 10.61 strikeouts per 9 innings pitched (4872 strikeouts in 4132 1/3 innings pitched).Second all time is Kerry Wood with 10.39 strikeouts per 9 innings pitched (1466 strikeouts in 1270 1/3 innings pitched) and third is Pedro Martinez with 10.05 strikeouts per 9 innings pitched (3152 strikeouts in 2823 1/3 innings pitched).
Nolan Ryan holds 5,714 strikeouts for his career and to this point no one else in the majors have struck out more than 5000 batters.
Randy Johnson: Entering the 2008 season, he was 56 strikeouts behind Roger Clemens for second all time. Through his August 6th start against Pittsburgh, he had 114 strikeouts for the season, closing the gap to Nolan Ryan (1st all-time) to slightly under 1,000 strikeouts. http://www.enth.com/Home.aspx?q=what+pitcher+has+the+most+strikeouts
Nolan Ryan has the most career strikeouts with 5,714.
In 2012, Justin Verlander of the Detroit Tigers, had the most strikeouts with 239.
Johan Santana with 265 strikeouts in 2004.
If you are talking about pitchers and who has the most K's, the answer is Nolan Ryan with 5,714 strikeouts. If you are talking about batters who have struck out at the plate, the leader is Reggie Jackson with 2,597 strikeouts.
Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
At the time of this question, Mark Buehrle had the most strikeouts, but currently Freddy Garcia does.
Sandy Koufax with 382 strikeouts in 1965.