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Here is a list of his many opponents Solid Snake has fought in the Metal Gear Solid series.
- Liquid Snake and the rouge FOXHOUND members (Psycho Mantis, Sniper Wolf, etc)
- Revolver Ocelot (MGS4 Liquid Ocelot)
- Big Boss (Naked Snake)
- Dead Cell Members (Vamp, Fortune, Fatman, and Former president of the USA Solidus Snake)
- The B&B Corps (Screaming mantis, Laughing Octopus, etc)
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