Persons who have been exposed to radiation, benzene, or radioactive thorium dioxide (a chemical used during certain diagnostic radiological procedures) are at risk for myelofibrosis
Myelofibrosis is usually not considered hereditary, as it is most commonly caused by acquired mutations in the bone marrow cells. However, there are rare genetic syndromes that can increase the risk of developing myelofibrosis. It is recommended to consult with a genetic counselor for personalized information regarding hereditary factors.
Myelofibrosis can progress to acute lymphocytic leukemia or lymphoma
Myelofibrosis goes by many names including idiopathic myelofibrosis, agnogenic myeloid metaplasia, chronic myelosclerosis, aleukemic megakaryocytic myelosis, and leukoerythroblastosis
Myelofibrosis is caused by an abnormality in a single stem cell, which causes it to grow out of control
Idiopathic myelofibrosis typically becomes progressively worse and can cause death
About one quarter of all patients with myelofibrosis have no symptoms (asymptomatic)
Myelofibrosis can lead to complications that may increase the risk of bleeding, including nosebleeds. This is often due to low platelet counts or issues with blood clotting associated with the condition. If you are experiencing frequent nosebleeds, it's important to consult a healthcare professional for evaluation and management.
Because symptoms are similar to other diseases (mostly leukemias), myelofibrosis is not easy to diagnose
Although historically there has not been much improvement in the treatment of myelofibrosis, that has changed recently. The main treatment now consists of taking a medication known as "Jakafi" which targets the gene thought to cause myelofibrosis.
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