Mrs. Washington
Eleanor Roosevelt
louisa Adams
My guess is Laura Bush..good question.
One Reagan, His first wife was Jane Wyman, then it was Nancy Reagan
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George Washington and John Adams were the first two US presidents.
If you are asking about the First Ladies (the wives of the presidents), they were Barbara Bush (wife of George H.W. Bush); Hillary Rodham Clinton (wife of Bill Clinton), and when the decade ended, the new First Lady would soon be Laura Bush (wife of George W. Bush).
Mrs. Herbert Hoover was named Lou.
Abigail Smith Adams , wife of John Adams and mother of John Quincy Adams.Barbara Pierce Bush, wife of George H. W. Bush and mother of George W. Bush.
Martha Washington was the wife of US President George Washington long before he became president. She was an aristocrat and became the first of the group called "First Ladies", meaning the wives of US Presidents.
Hillary Clinton, wife of President Bill Clinton, was elected to be a US Senator from New York. She resigned that job to become Secretary of State.