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Who proposed the base pairing rule?

Updated: 8/10/2023
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11y ago

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Watson and Crick came up with the base-pairing rule for nucleic acids using Chargaff's rule that in DNA the percentages of adenine and thymine are equal, and the percentages of guanine and cytosine are equal.

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12y ago
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13y ago

Erwin Chargaff discovered the basis for the base-pairing rule. This rule states that in DNA, Adenine always pairs with Thymine and Cytosine always pairs with Guanine. This rule was originally called Chargaff's rules, named so after the person who discovered them.

Chargaff made the discovery that the percentage of Adenine and Thymine in DNA was almost always the same, and that Cytosine and Guanine also were the same. While he didn't understand why at the time of his experiments, he provided a key piece of the puzzle into figuring out the structure of DNA.

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11y ago

Erwin Chargaff showed that the number of guanine units was equal to the number of cytosine units, and that the number of adenine was equal to the number of thymine. This hinted at a base pairing rule - but Chargaff did not explicitly state a rule.

Watson and Crick later proposed the base pairing rule.

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9y ago

Erwin Chargaff developed the rule that guanine and cytosine always occur in equal percentages, and adenine and thymine always occur in equal percentages, but James Watson and Francis Crick developed the base-pairing rule when they determined the structure of DNA.

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13y ago

Erwin Chargaff, who created "Chargaff's Ratios" to show that A=T and C=G.

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15y ago

Erwin Chargaff

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11y ago

Erwin Chargaff

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11y ago

Chargaff

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