Senator Bob Dole of Kansas.
Senator John McCain ran against Barack Obama for what became Obama's second term.
Lloyd Bentsen who was a Senator from Texas.
Senator Bob Dole of Kansas.
He was a candidate in 1948 as a conservative Republican from Ohio. He came from a political family that were isolationist and conservative. He ran against the liberal Republican, Thomas Dewey, governor of New York. He lost to Dewey easily. He ran again in 1952 against Dwight Eisenhower and lost again.
Calvin Coolidge, the Republican incumbent, defeated Wisconsin Senator Robert LaFollette of the Progressive Party and California Senator Hiram Johnson of the Democratic Party.
President George W. Bush ran against Senator John Kerry in 2004. President Bush won. Jim Carey, an actor, never ran for political office and never ran against any President of the USA.
Hubert Humphrey was a Democratic senator from Minnesota who ran against and lost to Richard Nixon in 1968.
George H. W. Bush defeated Dukakis in 1988.
Senator from Illinois who ran for president against Abraham Lincoln. Wrote the Kansas-Nebreaska Act and the Freeport Doctrine
Al Gore did not run in the 2004 Democratic primary. The candidates were John Kerry (Senator, MA), Robert Graham (Senator, FL), Carol Moseley Braun (former Senator, IL), Dick Gephardt (Representative, MO), Joe Lieberman (Senator, CT), Gen. Wesley Clark, Howard Dean (former Governor of VT), John Edwards (Senator, NC), Rev. Al Sharpton, Dennis Kucinich (Representative, OH), and the Honorable John Marx.
Robert Francis Kennedy (Bobby), who was John F. Kennedy's brother, ran for and won the seat of US Senator from New York in 1964. He served from 1965 until his death in 1968.