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This depends on the size and breed of such a dog, and the weight, strength, size and speed of each of the two men. Barehanded, the two men might have a chance if one distracts the dog and the other comes in behind to wrestle the dog to the ground, but even then such a vicious dog can wiggle free and wreak havoc on the men. If they (the men) have weapons, like a club or a knife, then they definitely will have a chance at winning such a fight.

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