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Because vinegar is acidic and water neutral, alka-seltzer will produce a better reaction in vinegar. This is because the alka-seltzer is basic with a ph of approx. 9.2 and vinegar is acidic with around 4 I think. Water has a ph of 7 making it neutral, and the higher the difference in numbers on ph scale, the bigger reaction(provided one is acidic(below 7) and one is basic(above 7)).

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Q: Why alka-seltzer in vinegar produces more bubbles than alka-seltzer in water?
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