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All action of neurotransmitter is eventually (mostly) manifest in the regulation of ion in nerve cell, to decide when to fire or not an action potential. Regulation of ion utilize the ion channel, and there are three (known) mechanism which affect the opening and closing of an ion channel :

1) direct influence - ion channel which is directly activated by neurotransmitter attached to them, this one is called ¨Transmitter Gated Channel¨

2) shortcut pathways - ion channel which is activated by G-protein, this is called the ¨G-protein-gated ion channels¨

3) second messenger cascades - G-protein trigger a chain reaction of chemical through enzyme or other class of protein and finally affect the opening and closing of ion channels

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11y ago
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Q: Why are G-protein-gated ion channels called the shortcut pathway?
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