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A famous answer would be from a cybernetic view:

An organism as a living system can reproduce itself and it creates a difference between itself and the environment (and thus creating bidirectional communication). In order to do that, it needs to be able to control and regulate itself. Only then it can be called an organism.

This is a functional approach, meaning that "non-organic" beings may be viewed as organisms aswell (such as machines or robots, but only when both requirements are fulfilled).

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