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Bioisosteres are molecules with a similar shape that have a similar biological effect. Their functional groups can be systematically replaced to investigate which structures have the desired properties such as high selectivity, less adverse effects, more metabolic stability, and less toxicity. The usage of bioisoteres can lead to a more simplified route to produce new drugs.
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Are pyrimidine and triazine rings bioisosteres?
Yes, pyrimidine and triazine rings are considered bioisosteres because they have similar geometries and sizes, allowing them to interact with biological targets in a comparable manner. They can be used interchangeably in drug design to modulate properties such as solubility, bioavailability, and potency.
What are the bioisosteres of the Me group?
They include the F, Cl, NH2, and OH group.
Definition of computer aided drug design?
Definition of computer aided drug design?
How does opiates show up in a drug screen?
The opiates is able to show up in a drug screen because of the technology used to design the testing kit.
What has the author A A Klesov written?
A. A. Klesov has written: 'Glycobiology and drug design' -- subject(s): Drugs, Glycomics, Carbohydrate drugs, Design, Drug development 'Internet' -- subject(s): Chemists, Biography, Internet 'Glycobiology and drug design' -- subject(s): Drugs, Glycomics, Carbohydrate drugs, Design, Drug development
What has the author John L LaMattina written?
John L. LaMattina has written: 'Drug truths' -- subject(s): Research Design, Drug Industry, Drugs, Drug development, Economics, Research, Pharmaceutical industry, Drug Design
What has the author Yvonne Connolly Martin written?
Yvonne Connolly Martin has written: 'Quantitative drug design' -- subject(s): Biopharmaceutics, Theoretical Models, Drugs, Drug Design, QSAR (Biochemistry), Design, Structure-activity relationships, Quantitative Structure-Activity Relationship 'Quantitative drug design' -- subject(s): Drugs, Structure-activity relationships, Biopharmaceutics, Theoretical Models, Drug Design, QSAR (Biochemistry), Design, Quantitative Structure-Activity Relationship, Mathematical models
Why are placebos not normally used in drug tests involving patients?
Placebos are often used in drug tests involving patients.Sometimes they are not used because of the test design (comparing against other treatments) or because of the seriousness of the condition, where a complete lack of treatment would be considered unethical.
Which of following jobs is a chemist most likely to have?
Drug design
What has the author RICHARD B SILVERMAN written?
RICHARD B. SILVERMAN has written: 'ORGANIC CHEMISTRY OF DRUG DESIGN AND DRUG ACTION'
What is the most used drug in Australia?
Alcohol is the most used legal drug. Of Illicit drugs the most widely used drug is cannabis.
What has the author Virginia M Litwin written?
Virginia M. Litwin has written: 'Flow cytometry in drug discovery and development' -- subject(s): Flow cytometry, Design, Methods, Drugs, Flow Cytometry, Pharmaceutical Chemistry, Drug Design
