Major cities are more prone to be located near the Mississippi river because of energy and water supply. The speed of the river can provide energy into that state, comically decreasing the amount of tax needed to pay for energy. This would be the same for water, since rivers have clean and drinkable water ready to go, it would be an amazing source of water, also heavily decreasing the amount of tax and money needed to pay for pipe and water supply.
It begins at Pittsburgh, Pennsylvania and runs to Cairo, Illinois where it meets the Mississippi River.
St. Louis, Missouri is the major city located along the Mississippi River at 38°N and 90°W. It is known for its iconic Gateway Arch and rich history as a major port city in the Midwest United States.
London
Santa Cruz
The Capitals (obviously)
located on the mouth of the Mississippi river
Burlington is the largest city.
Beijing and Shangai
Phoenix followed by Tucson.
Houston
guadalajara, monterrey and chihuahua
Vicksburg is a large town on the Mississippi River about halfway up the state of Mississippi. It is best known for a major civil war battle