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Why cefixime and clavulanic acid combination is better than cefixime alone?
Wiki User
∙ 13y ago
Cefixime and Clav- Has practically no rational. Primary because Cefixime is relatively stable against B-lactamase. Hence adding Clav to this combination is a worthless addition.
Wiki User
∙ 13y ago
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Use of cefixime and clavulanic acid combination?
cefixime and clavulanic acid can be used as a second line therapy where cefixime alone is not able to show it's bacteriocidal activity. Cefixime comes under beta lactum antibiotic category and gets degrade inpresence of beta lactumase enzyme, bacterias have developed resistance against cefixime by producing beta lactamase and ESBLs. Clavulanic acid is an irreversible inhibitor of beta lactamase enzyme and have mild antibiotic activity. when this combination is used, clavulanic acid inhibits beta lactamase enzyme and allow cefixime work as a bacteriocidal. the combination is very useful against cefixime resistant becteria. more research work is required to understand the further use of this combination and also to find out the superiority of this combination over Amoxi+Clav combination.
What is a Good broad spectrum antibiotic for dogs?
Amoxicillin alone, in combination with Clavulanic Acid, Quinolones like Enrofloxacin, Ciprofloxacin are good choices for initial therapy.
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Co-amoxiclav is classified as a combination antibiotic medication, which contains amoxicillin and clavulanic acid. It is used to treat bacterial infections that may be resistant to amoxicillin alone.
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Co amoxiclav contains amoxycillin (broader spectrum penicillin antibiotic) and clavulanic acid a beta-lactamase inhibitor. The combination is effective in infection caused by beta lactamase producing pathogen such H. influenzea, A. auareus and A. pneuomonea. If amoxicillin is given alone then betalactamse can destroy this drug making it ineffective. The combination has no efficacy against allergic skin rashes, rather penicillin may cause skin rashes. however it may be effctive in the treat of skin infection such as injury, acne etc.
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