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Cefixime and Clav- Has practically no rational. Primary because Cefixime is relatively stable against B-lactamase. Hence adding Clav to this combination is a worthless addition.

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Use of cefixime and clavulanic acid combination?

cefixime and clavulanic acid can be used as a second line therapy where cefixime alone is not able to show it's bacteriocidal activity. Cefixime comes under beta lactum antibiotic category and gets degrade inpresence of beta lactumase enzyme, bacterias have developed resistance against cefixime by producing beta lactamase and ESBLs. Clavulanic acid is an irreversible inhibitor of beta lactamase enzyme and have mild antibiotic activity. when this combination is used, clavulanic acid inhibits beta lactamase enzyme and allow cefixime work as a bacteriocidal. the combination is very useful against cefixime resistant becteria. more research work is required to understand the further use of this combination and also to find out the superiority of this combination over Amoxi+Clav combination.


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