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Column chromatography does separate polar compounds. Use

EtOAc : MeCN : MeOH : water (relative volumes, not percentages)

60 : 20 : 20 : 20

60 : 15 : 15 : 15

60 : 10 : 10 : 10

70 : 10 : 5 : 5

70 : 5 : 2.5 : 2.5

70 : 2.5 : 1.25 : 1.25

If streaking occurs, or if you are trying to purify an acid with

limited solubility in these systems, it sometimes helps to add 0.5%

triethylamine. Reference: external link

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Q: Why column chromatography doesn't separate polar compounds?
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