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They had never before been exposed to them so their immune systems had no immunity at all and could not respond to the infections.

In Europeans diseases like Smallpox had about a 30% fatality rate, in the Americans had a fatality rate exceeding 90% and in Europeans diseases like Measles, Mumps, and German Measles had only a tiny fatality rate, in the Americans had fatality rates exceeding 50%. These diseases totally decimated the native American population and kept it down for several generations, until a small degree of immunity began to develop in the survivors.

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