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Why do African and Mediterranean get sickle cell anemia more often?
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How often doese sickle cell anemia occur in the population?
Sickle cell anemia is found in approximately 1 in 5000 people. It is mostly found in people from Sub-Saharan Africa do to the nature of the disease providing resistance to malaria.
Will your infant die from sickle cell?
Although Sickle Cell Anemia sufferer's often have a shorter life expectancy, infants do not usually die from it. However it is important to get blood tranfusions.
Does sickle cell anemia affect certain groups of people more than others?
It affects those who are carriers as well as those who have the disease fully. Carriers though have both sickle cell blood cells and normal ones, and therefore can usually function just like other people would. It is most often seen in African-Americans.
When do you see hematopoietic hyperplasia?
Most often, hematopoietic hyperplasia is found in patients who have sickle cell anemia. Although rare, it does show up from time to time.
Who does Sickle Cell Anemia effect?
Sickle-cell disease, usually presenting in childhood, occurs more commonly in people (or their descendants) from parts of tropical and sub-tropical regions where malaria is or was common. The prevalence of the disease in the United States is approximately 1 in 5,000, mostly affecting Americans of Sub-Saharan African descent. In simplified terms usually black people.
Where is a Pedigree chart for sickle cell anemia?
An example pedigree chart for sickle-cell anaemia can be found using the related link below. Individuals shaded black have the disease, individuals that are not shaded are unaffected, and individuals that are carriers are shown with diagonal lines (they are often shown with a single dot in the centre of their shape).
What are the benefits of sickle cell trait?
sickle cell trait is caused by two recessive alleles - meaning both partns must give resessive trait DNA o their child. - sickle cell anemia dose not have a benefit - or if it dose it is out waysd by the fact that people with sickle cell have very low blood oxygen as their blood cellsare dis-formed. however, if there is only one allele- ie they have A and b alleles for sickle cell. then they are more immune to malaria. a deadly parasite passed by misquotes in tropical countries.
Does anemia eventually become a blood disorder?
Anemia is a blood disorder, but is often easily controlled and temporary. In women of childbearing age, anemia is often due to iron deficiency.
Why do sickle cell anemia cause so many problems?
A sickle cell is a malformed red blood cell. It is caused by a mutated gene inherited from one or both parents. If inherited from both parents the red cells are very malformed, causing sickle-cell anaemia. This is a serious illness, causing weakness and shortness of breath and often leading to an early death.Mutations like this are usually steadily removed from the gene pool because those with it tend to have fewer children. The sickle-cell gene remains in the gene pool because those who get it from only one parent have a slightly deformed red-cell. This causes only limited problems for the bearer, and has one large advantage - it makes the red-cell taste nasty to the malaria parasite. In other words, it protects against malaria which is otherwise often fatal.In areas where malaria is endemic it is common to find the sickle cell gene in about 15% of the population. When Africans came to the USA as slaves the gene came with them. However, malaria has never been common in the US, and the percentage of sickle-cell gene in black Americans has decreased steadily.
How is malaria and sickle cells related?
Sickle cell anemia cause red blood cells to be shaped like sickles. malaria can't enter these cells which gives the person an immunity to malaria.
What type of mutation causes sickle cells disease?
Sickle cell anemia is an inherited disease. People who have the disease inherit two copies of the sickle cell gene-one from each parent. The sickle cell gene causes the body to make abnormal hemoglobin. Hemoglobin is the iron-rich protein that gives blood its red color and carries oxygen from the lungs to the rest of the body. In sickle cell anemia, the hemoglobin sticks together when it delivers oxygen to the body's tissues. These clumps of hemoglobin are like liquid fibers. They cause the red blood cells to become stiff and shaped like a sickle, or "C." The sickled red blood cells tend to stick together and get caught in the blood vessels. (Other cells also may play a role in this process.) Two copies of the sickle cell gene are needed for the body to make the abnormal hemoglobin found in sickle cell anemia.
Which condition is often an indication of iron-deficiency anemia?
Koilonychia!
