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It is the reference sequence (as opposed to a genbank sequence) for an mRNA. It has been curated by the nice people at NCBI to act as a baseline for the scientific community. See http://www.ncbi.nlm.nih.gov/projects/RefSeq/RSfaq.html for further explanation.

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Q: Why do RefSeq accession numbers for mRNA sequences start with the letters NM in particular?
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