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Primary biliary cirrhosis is the gradual destruction of the biliary system for unknown reasons.
Ninety percent of patients with this disease are women between the ages of 35 and 60.
It represents 15-20% of all cirrhosis
yes
In some patients, the disease destroys the liver in as little as five years. In others, it may lie dormant for a decade or more.
It is a progressive disease characterized by destruction of small bile ducts
Increased levels of bilirubin in the urine may be due to: * Biliary strictures * Cirrhosis * Gallstones in the biliary tract * Hepatitis with associated biliary obstruction * Surgical trauma affecting the biliary tract * Tumors of the liver or gall bladder
Ursodeoxycholic acid, a chemical that dissolves gall stones, provides substantial symptomatic relief. It is still unclear if it slows liver damage. Patients also do well with liver transplantation.
Between 30% and 70% of hepatoma patients also have cirrhosis.
Fifty percent of patients with cirrhosis will develop ascites over a period of 10 years.
Itching is caused by a buildup of bile in the skin and fatigue are early symptoms.
Scarring or abnormality of the biliary system accounts for roughly 20% of the patients who need a liver transplantation.