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Alcohol affects women more quickly because they generally have a higher proportion of body fat compared to men. Because fat can't absorb alcohol, higher levels of it are concentrated in the blood. Females also have less dehydrogenase, a substance that breaks down alcohol before it can enter the blood. This means that women absorb nearly 30% more alcohol into their blood than do men who have the same height and weight who consume the same quantity of alcohol in the same time period. Females also tend to be shorter and lighter than men, which also concentrates alcohol in their blood more quickly.

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