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First reason for polyphagia is the intracellular starvation. As in Diabetes either there is absence or the resistance to insulin action so glucose cannot move into the cells and thus cells are starved of glucose.

Second reason can be the "Glucostat theory of feeding regulation". According to this theory arteriovenous difference of glucose in the hypothalamic satiety and feeding centers regulate the feeding response. If the difference is high due to the reason that glucose is more utilized by satiety center, the satiety center is activated. And if the difference is low then feeding center is activated. In diabetes due to insulin resistance or absence of insulin, glucose cannot move into the satiety center thus the arteriovenous difference remains low and the feeding center is chronically active.

Thus polyphagia occurs.

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9y ago
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11y ago

Polydipsia, or excessive thirst, is the result of dehydration. The dehydration is in turn caused by prolonged periods of hyperglycemia (high blood sugar). Normally, the glucose in the blood is used by the body as fuel. When the blood sugar levels reach over 180mg/dl, the body tries to find other ways to eliminate the excess sugar. One of the ways is through the kidneys, thus polyuria (abnormally large production or passage of urine)

occurs. To replace the lost fluids, the body demands more water, resulting in polydipsia. Note that polydipsia is a symptom of hyperglycemia for type 1 diabetes and does not occur if the blood sugar levels are kept in check.

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13y ago

Diabetes mellitus' main symptom is hyperglycemia and this causes blood hyperosmolarity.This condition activates the thirst center in hypothalamus and makes the subject drink excessive water.

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13y ago

it is because it does!

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Q: Why does polydipsia occur with diabetes mellitus?
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