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First reason for polyphagia is the intracellular starvation. As in Diabetes either there is absence or the resistance to insulin action so glucose cannot move into the cells and thus cells are starved of glucose.

Second reason can be the "Glucostat theory of feeding regulation". According to this theory arteriovenous difference of glucose in the hypothalamic satiety and feeding centers regulate the feeding response. If the difference is high due to the reason that glucose is more utilized by satiety center, the satiety center is activated. And if the difference is low then feeding center is activated. In diabetes due to insulin resistance or absence of insulin, glucose cannot move into the satiety center thus the arteriovenous difference remains low and the feeding center is chronically active.

Thus polyphagia occurs.

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