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Only small and uncharged particles can pass through the nonpolar part of the membrane interior. Ions are charged and won't pass through a membrane by passive diffusion. Certain ions do pass through membranes by other mechanisms, though.

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βˆ™ 13y ago
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βˆ™ 11y ago

Ions are charged, so they cannot diffuse through the hydrophobic core of the membrane.

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βˆ™ 10y ago

Because the middle layer of the lipid bilayer is apolar.

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Q: Why don't ions pass through cell membran?
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