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Why is KHP used as a primary standard for non aqueous titration?
Wiki User
∙ 13y ago
KHP (potassium hydrogen phthalate) is available extremely pure (which is always good for a primary standard) and gives a very sharp end-point especially with Crystal Violet Indicator
Wiki User
∙ 13y ago
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Why you use titration?
Titration is used to calculate the molarity of an acid or base (standardising), using a base or an acid respectively with a known molarity (primary standard).
How do they use non-aqueous titration in pharmaceutical application?
Non-aqueous titration is used in pharmaceutical applications to determine the purity and concentration of certain drugs or active pharmaceutical ingredients. This technique involves using a non-aqueous solvent, such as methanol or acetonitrile, as the titrant and titrating it against a solution containing the drug or active ingredient. Non-aqueous titration is particularly useful for compounds that are not soluble in water or are prone to hydrolysis in an aqueous medium.
What is a standard solution in an acid-base titration?
It is a solution of known concentration. In acid base titrations we used KHP as the acid standard. We weighed it to 0.1 mg and made the solution up to a certain volume in a volumetric flask. We then standardized the base by titration. KHP was thus the primary standard and NaOH the secondary std.
What do mean by dichromatometry?
Dichromatometry is a kind of titration used in analytical chemistry, where Potassium Dichromate (K2Cr2O7), a primary standard substance solution is used for estimation of mainly metal ions, like Fe+2 etc. As dichromate is used as the titrating substance, the name dichromatometry. Mainly BDS (Barium Diphenylamine Sulphonate) indicator is used in this kind of titration.
What is non aqueous titration?
Nonaqueous titration is the titration of substances dissolved in nonaqueous solvents. It is the most common titrimetric procedure used in pharmacopoeial assays and serves a double purpose: it is suitable for the titration of very weak acids and very weak bases, and it provides a solvent.
Why you use titration?
Titration is used to calculate the molarity of an acid or base (standardising), using a base or an acid respectively with a known molarity (primary standard).
How do they use non-aqueous titration in pharmaceutical application?
Non-aqueous titration is used in pharmaceutical applications to determine the purity and concentration of certain drugs or active pharmaceutical ingredients. This technique involves using a non-aqueous solvent, such as methanol or acetonitrile, as the titrant and titrating it against a solution containing the drug or active ingredient. Non-aqueous titration is particularly useful for compounds that are not soluble in water or are prone to hydrolysis in an aqueous medium.
What is a standard solution in an acid-base titration?
It is a solution of known concentration. In acid base titrations we used KHP as the acid standard. We weighed it to 0.1 mg and made the solution up to a certain volume in a volumetric flask. We then standardized the base by titration. KHP was thus the primary standard and NaOH the secondary std.
What do mean by dichromatometry?
Dichromatometry is a kind of titration used in analytical chemistry, where Potassium Dichromate (K2Cr2O7), a primary standard substance solution is used for estimation of mainly metal ions, like Fe+2 etc. As dichromate is used as the titrating substance, the name dichromatometry. Mainly BDS (Barium Diphenylamine Sulphonate) indicator is used in this kind of titration.
Why is potassium permanganate used in titration experiment despite being a secondary standard solution?
kmno4 is very good oxidizing agent. that means it is easily reduced by any other reagent. so it can't be considered as primary standard as its concentration changes upon free leaving
What is non aqueous titration?
Nonaqueous titration is the titration of substances dissolved in nonaqueous solvents. It is the most common titrimetric procedure used in pharmacopoeial assays and serves a double purpose: it is suitable for the titration of very weak acids and very weak bases, and it provides a solvent.
Why is nitric acid not often used as a standard solution for neutralization titrations?
The usual primary standard for acid-base titration is sulfuric acid. Nitric acid tends to lose NO2 by volatilization and HCl is also more volatile.
Difference between advantages and disadvantages of non aqueous and aqueous titration?
The advantage of non-aqueous media titrations is that often the end point is much more satisfactory to the person doing the experiment. Another advantage is that mediums that are not soluble in water can be used.
Is EDTA considered as a primary standard?
No. Chemical compounds have to fulfill a number of requirements before they can be classified and used as a primary standard: A primary standard in chemistry is a reliable, readily quantified substance. Features of a primary standard include: 1. High purity 2. Stability (low reactivity) 3. Low hygroscopicity and efflorescence 4. High solubility (if used in titration) 5. High equivalent weight 6. Non-toxicity 7. Ready and cheap availability Edta and particularly the sodium salts of EDTA which are frequently used do not fulfill the first requirement. Therefore the solution of EDTA has to be standardised against a known and accepted primary standard.
Is hcl praimary standard or secondary standard?
HCl is not used as a primary standard
Why is ortho phosphoric acid used in titration?
Phosphoric acid is used in titraions involving Iron(III) ion. Ferric ions are not stable in aqueous medium. It forms a stable complex with phosphate ions.
What primary standard is used to titrate against potassium hydroxide?
HCl, hydrochloric acid, is the primary standard used to titrate against potassium hydroxide.
