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I believe that it is beneficial to be heterozygous for the condition, since a slight mutation of the CFTR protein still occurs, provinding resistance to diseases such as typhoid fever and cholera. This is because the pathogens for the fever cannot enter through the mutated CFTR protein in the intestinal epithelium. This has increased (or rather "not decreased") the rate of carriers, and therefore the faulty recessive allele is "still around"

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13y ago
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12y ago

For decades and decades. So, for a long time.

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Q: Why is cystic fibrosis still around?
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