Thyroxine is the precursor to active thyroid hormone, which is essential for life. Thyroid hormone also plays an important role in brain development. A child with untreated low thyroid hormone (hypothyroidism) will develop a condition known as cretinism, which is marked by severe physical and mental abnormalities.
thyroxine
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blood level gets low
High levels of thyroxine in the blood negatively feedback to the pituitary gland, reducing the secretion of thyroid-stimulating hormone (TSH). Conversely, low levels of thyroxine signal the pituitary gland to increase TSH secretion to stimulate the thyroid gland to produce more thyroxine.
The target for thyroxine is to regulate the body's metabolism by controlling the production of thyroid hormones. Thyroxine is produced by the thyroid gland and helps to maintain normal function of organs and tissues in the body. The target level of thyroxine in the blood is typically determined through thyroid function tests.
Thyroid function - Hypothyroidism. A low level of thyroxine and high level of TSH indicate an underactive thyroid.
When the level of the thyroxine increase, the level of the thyroid stimulating hormone decrease. So in turn the level of the thyroid hormone decreases. When the level of the thyroxine decrease, the level of the thyroid stimulating hormone increase. This in turn increase the level of the thyroxine. This explanation does not explain to how the level of the hormone is regulated at that particular level. But then this explanation satisfy most of the people.
A T4 assay is used to measure the level of the hormone thyroxine (T4) in the blood, which helps to assess thyroid function. Abnormal T4 levels can indicate conditions such as hypothyroidism or hyperthyroidism.
it is important to maintain blood sugar level
When a drop in the level of hormones in the body occurs, it causes a chain reaction of responses. It is called negativefeedback because it causes system output to oppose system input, rather than support it.Example: Thyroxine (a thyroid hormone) level in the blood drops. The hypothalamus then sends out an order for TSH (thyroid stimulating hormone) to the anterior pituitary gland. The pituitary releases the TSH. TSH then causes the thyroid to start producing thyroxine again. When the blood level rises, the hypothalamus stops producing TSH, causing the thyroid to stop producing thyroxine. This happens in a loop until stabilization occurs.
A negative feedback system works by detecting changes in a physiological variable and activating mechanisms to counteract those changes, maintaining homeostasis. In the case of regulating thyroxine levels in the blood, if the concentration of thyroxine becomes too high, the hypothalamus reduces the release of thyrotropin-releasing hormone (TRH), which in turn decreases the secretion of thyroid-stimulating hormone (TSH) from the pituitary gland. This leads to a decrease in thyroid hormone production by the thyroid gland, helping to restore normal thyroxine levels in the blood.
When the amount of a particular hormone in the blood is reaches a certain level, the endocrine system sends signals to stop the release of that hormone. "Pearson Education Inc."