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A screening drug test is (as the name suggests) a way of determining who may be positive for a particular drug and who is demonstrably negative.

A screening drug test is a sort of "big net". It catches the people positive for a drug, but also catches those who may not be truly positive as well.

In drug testing circles, this state of being found possibly positive for a particular drug on the basis of a screening test is sometimes referred to as being "non-negative" for a particular drug of interest.

The proper response to a "non-negative" drug screen is to send the sample for confirmation testing. This process involves a much more detailed analysis that often includes subjecting the sample (often urine) to gas chromatography and mass spectrometry to determine whether the (presumptive) non-negative screening test is, in fact, POSITIVE for the drug of concern.

Once the confirmatory test is complete, a certified Medical Review Officer (MRO) will sometimes contact the donor of the sample to determine if there is some medically-acceptable reason that the urine (or other donated sample) contained a particular drug.

If the drug test was properly-performed, this constitutes a way of determining (from a legal perspective) if the drug test was truly "positive".

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Q: Why is screening test for drug is not conclusive test?
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