If the roads are busy, it could take up to 2 hours.Here is the route:Take U.S. 442 EAST to I-76 EAST to PHILADELPHIA. Follow signs.Take I-76 (Schuylkill Expwy) EAST to Philadelphia.
75 miles taking this route:Take U.S. 222 NORTH from Lancaster to PENNSYLVANIA TURNPIKE (toll road) I-76. Follow signs to I-76 PENNSYLVANIA TURNPIKE, then follow signs to I-76 EAST to PHILADELPHIA.Take the PENNSYLVANIA TURNPIKE (toll road) EAST on I-76, and on I-276, to PA-611 to DOYLESTOWN and JONESTOWN at EXIT 343 (WILLOW GROVE exit). Follow signs to PA-611 NORTH to DOYLESTOWN.Take PA-611 NORTH to HORSHAM.
20 miles across I-76 PENNSYLVANIA TURNPIKE (toll road) EAST.
About 47 miles taking this route:Take U.S. 322 EAST, from Honey Brook, to U.S. 30 EAST.Take U.S. 30 EAST to U.S. 202 NORTH towards KING OF PRUSSIA.Take U.S. 202 NORTH to I-76 EAST to PHILADELPHIA.Take I-76 EAST to PHILADELPHIA.
289 miles taking this route:Go across to I-76 PENNSYLVANIA TURNPIKE (toll road), via Freeport Road. Once you are on the entrance ramp to the turnpike, stay right and go onto I-76 EAST towards HARRISBURG.Take I-76 EAST, on the PENNSYLVANIA TURNPIKE, to U.S. 22 at EXIT 57 (the PITTSBURGH exit), near Monroeville; follow signs to U.S. 22 EAST to MURRYSVILLE.Take U.S. 22 EAST to I-99 NORTH towards ALTOONA (to I-80).Take I-99 NORTH to I-80 EAST to WILLIAMSPORT.Take I-80 EAST to PA-715 at EXIT 299 in TANNERSVILLE; turn left off the exit ramp onto PA-715 NORTH.Take PA-715 NORTH to Henryville.
I-84 East to I-80 East Take I-76 East (the Pennsylvania Turnpike) to Exit 29 Follow the signs to Pittsburgh.
95 miles taking this route:Take PA-61 SOUTH from Pottsville to I-78 EAST to ALLENTOWN in Hamburg.Take I-78 EAST to I-476 PENNSYLVANIA TURNPIKE (NE Extension) at EXIT 51; follow signs to I-476 PENNSYLVANIA TURNPIKE (toll road), then, once you are on the exit ramp to the PENNSYLVANIA TURNPIKE, follow signs to I-476 SOUTH to PHILADELPHIA.Take I-476 PENNSYLVANIA TURNPIKE (toll road) SOUTH to I-76 EAST to PHILADELPHIA at EXIT 16; follow signs on the exit ramp to I-76 EAST to PHILADELPHIA.Take I-76 EAST (Schuykill Expwy) to Philadelphia.
430 miles taking this route:Take I-70 EAST, from Columbus, to I-76 PENNSYLVANIA TURNPIKE (toll road) EAST to HARRISBURG, via I-470 EAST (EXIT 219 in OHIO) to bypass WHEELING.Take I-76 EAST, on the PENNSYLVANIA TURNPIKE, to PA-283 at EXIT 247 (the HARRISBURG EAST interchange); stay right off the exit ramp, and go onto PA-283 EAST to LANCASTER.Take PA-283 EAST to U.S. 30 EAST to PHILADELPHIA, near Lancaster.Take U.S. 30 EAST to COATESVILLE.
197 miles taking this route:Take PA-982 SOUTH, from Latrobe, to PA-31 EAST to DONEGAL.Take PA-31 EAST to the PENNSYLVANIA TURNPIKE (I-76); follow signs to I-76 EAST to HARRISBURG (to EXITS 110-359).Take I-76 PENNSYLVANIA TURNPIKE (toll) - EAST to I-83 SOUTH to YORK off EXIT 242 (the HARRISBURG WEST interchange).Take I-83 SOUTH to U.S. 30 WEST to GETTYSBURG off EXIT 22 in York.Take U.S. 30 WEST across to the EXIT for PA-74 CARLISLE AVE; take the exit, and then turn left off the exit ramp onto PA-74 CARLISLE AVE - SOUTH.Take PA-74 CARLISLE AVE - SOUTH to York Fairgrounds.
328 miles taking this route:Take U.S. 422 EAST from Parkman to SR-5/82; TURN RIGHT onto SR-5/82 WEST to RAVENNA.Take SR-5 WEST to I-80 OHIO TURNPIKE (toll road). Follow signs to OHIO TURNPIKE (toll), then stay right past the toll booth on the exit ramp to get onto I-80 EAST.Take the OHIO TURNPIKE (toll road) EAST on I-80, then EAST on I-76 to PENNSYLVANIA, where I-76 continues EAST as the PENNSYLVANIA TURNPIKE (toll road).Continue EAST on the PENNSYLVANIA TURNPIKE on I-76 to PA-283 at EXIT 247 (HARRISBURG EAST exit). Stay right past the toll booth to get onto PA-283 EAST to LANCASTER.Take PA-283 EAST to Lancaster.
133 miles taking this route:Take I-83 NORTH from York to I-76 PENNSYLVANIA TURNPIKE (toll road) to PHILADELPHIA and PITTSBURGH off EXIT 39B. Once you are on the ramp, follow signs to I-76 EAST to PHILADELPHIA.Follow the PENNSYLVANIA TURNPIKE (toll road) EAST on I-76, then on I-276 to PA-611 to DOYLESTOWN and JENKINTOWN at EXIT 343 (WILLOW GROVE exit). Once you are past the toll booths on the exit ramp, follow signs to PA-611 NORTH to DOYLESTOWN.Follow PA-611 NORTH to PA-132 (STREET ROAD). Turn right onto PA-132 EAST.Take Street Rd to Southampton.
150 miles taking this route:Take U.S. 219 SOUTH, from Dubois, to U.S. 22 EAST to HOLLIDAYSBURG.Take U.S. 22 EAST to I-99 SOUTH to BEDFORD.Take I-99 SOUTH to I-70/I-76 PENNSYLVANIA TURNPIKE (toll road) at EXIT 1; follow signs to I-70/I-76 PENNSYLVANIA TURNPIKE - EAST towards HARRISBURG.Take I-70/I-76 EAST, on the TURNPIKE, to U.S. 30 at EXIT 161, which is the BREEZEWOOD interchange; EXIT, and follow signs to U.S. 30 EAST to CHAMBERSBURG and GETTYSBURG.Take U.S. 30 EAST to McConnellsburg.