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Try separating the mice. The mouse being aggressive is probably wanting morespace to itself, or coming on baby making (baby part depends on if it's old or young and if it has lived with males before). Make shure the aggresive one is female. Male are always aggresive with another mouse. the last reason is that it might have gotten a little lonley with out human company. At the place you bought them they probably got much attention, and now not as much.

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Q: Why is your female mouse becoming aggressive You got 3 fem. mice 2 months ago working on being social with themnot on daily basis washes hands 1st. Why is one of the mice becoming very aggressive?
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