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The people who were responsible for the defeat of the Aztec's emperor and empire were the Spanish.
The Spanish brought diseases which weakened or killed thousands of native people. Also the Spanish brought big horses that the Aztec were terrified. The third factor was that they had new and stronger armor and weapons.
By outnumbering them
The Spanish defeat of the Aztec Empire was led by Hernan Cortes in April of 1520. He was accompanied by a man named Pizarro.
Small Pox
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Easy answer. Better technology. The Incas and Aztecs used cloth clothing and primitive arms, while as the Spanish used guns and plated armor.
they were able to defeat the inca and the aztec because the spanish had more tecnology such as great guns and they were skilled horse riders. plus they had diseases that wiped out most of them.
La Malinche, also known as Doña Marina, was the Native American interpreter who helped the Spanish conquer the Aztec Empire led by Hernán Cortés in the early 16th century. She played a crucial role in facilitating communication between the Spanish and various indigenous groups in Mesoamerica.