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CO2 is what causes the drive to breathe in normal human. In carbon monoxide poisoning, there are two reasons why the ventilatory pattern may remain unchanged: there is an initial decrease in CO2 as the body reserves become mobilized telling the chemoreceptors and the apneustic center in the brain that no more ventilation is required. The second reason is the CO poisoning cause a cerbrospinal acidosis which can further hinder signals from the apneustic center to the respiratory system.

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Q: Why respiratory rate not increase in carbon monoxide poisoning?
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